Oracle Healthcare Acquisition Corp. ▼

AGREEMENT AND PLAN OF MERGER

among

ORACLE HEALTHCARE ACQUISITION CORP.,

PTI ACQUISITION SUB, INC.,

and

PRECISION THERAPEUTICS, INC.

Dated as of December 3, 2007

TABLE OF CONTENTS

ARTICLE I.     THE MERGER

Section 1.1.

Section 1.2.

Section 1.3.

AMENDMENT NO. 1

TO

AGREEMENT AND PLAN OF MERGER

THIS AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER (this �Amendment�) is made and entered into as of January 24, 2008 by and among Oracle Healthcare Acquisition Corp., a Delaware corporation (�Parent�), PTI Acquisition Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent (�Merger Sub�), Precision Therapeutics, Inc., a Delaware corporation (the �Company�), and Joel P. Adams (the �Stockholder Representative�).  . . .

AMENDMENT NO. 1

TO

AGREEMENT AND PLAN OF MERGER

THIS AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER (this �Amendment�) is made and entered into as of January 24, 2008 by and among Oracle Healthcare Acquisition Corp., a Delaware corporation (�Parent�), PTI Acquisition Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent (�Merger Sub�), Precision Therapeutics, Inc., a Delaware corporation (the �Company�), and Joel P. Adams (the �Stockholder Representative�).  . . .

NON-EXCLUSIVE LICENSE AGREEMENT

This Agreement is made and entered into as of the 1st day of November, 2007 (�Effective Date�), by and between the University of Pittsburgh � Of the Commonwealth System of Higher Education, a non-profit corporation, organized and existing under the laws of the Commonwealth of Pennsylvania, having an office at 200 Gardner Steel Conference Center, Thackeray and O�Hara Street, Pittsburgh, Pennsylvania 15260 (�University�), and Precision Therapeutics, Inc, having its principal office at 2516 Jane Street, Pittsburgh, PA 15203 (�Licensee�).

WHEREAS, University is  . . .

787 Seventh Avenue

New York, NY 10019-6099

February 6, 2008

Oracle Healthcare Acquisition Corp.

200 Greenwich Ave., 3^rd Floor

Greenwich, CT 06830

Ladies & Gentlemen:

We have acted as counsel for Oracle Healthcare Acquisition Corp., a Delaware corporation, in connection with (i) the Merger, as defined and described in the Agreement and Plan of Merger, dated as of  . . .

787 Seventh Avenue

New York, NY 10019-6099

February [    ], 2008

Oracle Healthcare Acquisition Corp.

200 Greenwich Ave., 3^rd Floor

Greenwich, CT 06830

Ladies & Gentlemen:

We have acted as counsel for Oracle Healthcare Acquisition Corp., a Delaware corporation, in connection with (i) the Merger, as defined and described in the Agreement and Plan  . . .

REGISTRATION RIGHTS AGREEMENT

THIS REGISTRATION RIGHTS AGREEMENT (this �Agreement�) is entered into as of the           day of               , 2006, by and among Oracle Healthcare Acquisition Corp., a Delaware corporation (the �Company�), and the undersigned parties listed under Investors on the signature page hereto (each, an �Investor� and collectively, the �Investors�).

WHEREAS, the Investors currently hold all of the issued and outstanding securities of the  . . .

REGISTRATION RIGHTS AGREEMENT

THIS REGISTRATION RIGHTS AGREEMENT (this �Agreement�) is entered into as of the           day of               , 2005, by and among Oracle Healthcare Acquisition Corp., a Delaware corporation (the �Company�), and the undersigned parties listed under Investors on the signature page hereto (each, an �Investor� and collectively, the �Investors�).

WHEREAS, the Investors currently hold all of the issued and outstanding  . . .